Adele Boskey, PhD

Appointments

Starr Chair, Mineralized Tissue Research, Hospital for Special Surgery

Director, Mineralized Tissue Laboratory, Hospital for Special Surgery

Program Director, Musculoskeletal Integrity Program, Hospital for Special Surgery

Professor, Biochemistry, Weill Medical College of Cornell University

Professor, Graduate Program in Physiology, Biophysics, and Systems Biology, Weill Medical College of Cornell University

Professor, Graduate Center for Biomedical Engineering, City College of New York

Professor, Field of Biomechanical Engineering, College of Engineering, Cornell University

 

Selected Publications

Bahar H, Yaffe A, Boskey A, Binderman I. Influence of bone-derived matrices on generation of bone in an ectopic rat model. J Orthop Res. 2010 May;28(5):664-70. 

Boskey AL, Coleman R. Aging and Bone. J Dent Res. 2010 Oct 5. [Epub ahead of print] 

Burket J, Gourion-Arsiquaud S, Havill LM, Baker SP, Boskey AL, van der Meulen MC. Microstructure and nanomechanical properties in osteons relate to tissue and 

animal age. J Biomech. 2010 Nov 11. [Epub ahead of print]  

Chen IP, Wang CJ, Strecker S, Koczon-Jaremko B, Boskey A, Reichenberger EJ. Introduction of a Phe377del mutation in ANK creates a mouse model for

craniometaphyseal dysplasia. J Bone Miner Res. 2009 Jul;24(7):1206-15.  

Donnelly E, Chen DX, Boskey AL, Baker SP, van der Meulen MC. Contribution of mineral to bone structural behavior and tissue mechanical properties. Calcif

Tissue Int. 2010 Nov;87(5):450-60.  

Donnelly E, Boskey AL, Baker SP, van der Meulen MC. Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex. J Biomed Mater Res A. 2010 Mar 1;92(3):1048-56.  

Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL. Different forms of DMP1 play distinct roles in mineralization. J Dent 

Res. 2010 Apr;89(4):355-9.  

Gourion-Arsiquaud S, Faibish D, Myers E, Spevak L, Compston J, Hodsman A, Shane E, Recker RR, Boskey ER, Boskey AL. Use of FTIR spectroscopic imaging to

identify parameters associated with fragility fracture. J Bone Miner Res. 2009 Sep;24(9):1565-71.  

Hosogane N, Huang Z, Rawlins BA, Liu X, Boachie-Adjei O, Boskey AL, Zhu W. Stromal derived factor-1 regulates bone morphogenetic protein 2-induced

osteogenic differentiation of primary mesenchymal stem cells. Int J Biochem Cell Biol. 2010 Jul;42(7):1132-41.  

Ibarra M, Chou PM, Pachman LM, Zhao YD, Boskey AL. Calcification in a case of circumscribed myositis ossificans. J Rheumatol. 2010 Apr;37(4):876.  

Reumann MK, Nair T, Strachna O, Boskey AL, Mayer-Kuckuk P. Production of VEGF receptor 1 and 2 mRNA and protein during endochondral bone repair is differential and healing phase specific. J Appl Physiol. 2010 Oct 14. [Epub ahead of print]

Roy R, Kudryashov V, Binderman I, Boskey AL. The role of apoptosis in mineralizing murine versus avian micromass culture systems. J Cell Biochem. 2010 

Oct 15;111(3):653-8. 

 
Roy R, Boskey A, Bonassar LJ. Processing of type I collagen gels using nonenzymatic glycation. J Biomed Mater Res A. 2010 Jun 1;93(3):843-51. P

Roy R, Kudryashov V, Doty SB, Binderman I, Boskey AL. Differentiation and mineralization of murine mesenchymal C3H10T1/2 cells in micromass culture.

Differentiation. 2010 Apr-Jun;79(4-5):211-7.  

Tsay J, Yang Z, Ross FP, Cunningham-Rundles S, Lin H, Coleman R, Mayer-Kuckuk P, Doty SB, Grady RW, Giardina PJ, Boskey AL, Vogiatzi MG. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood. 2010 Oct 7;116(14):2582-9.  

Vogiatzi MG, Tsay J, Verdelis K, Rivella S, Grady RW, Doty S, Giardina PJ, Boskey AL. Changes in bone microarchitecture and biomechanical properties in the 

th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual. Calcif Tissue Int. 2010 Jun;86(6):484-94.  

Zhao Y, Urganus AL, Spevak L, Shrestha S, Doty SB, Boskey AL, Pachman LM. Characterization of dystrophic calcification induced in mice by cardiotoxin.

Calcif Tissue Int. 2009 Sep;85(3):267-75. 

For more publications, please see the PubMed listing.  

Research Description

Mineralization Mechanisms

Dr. Boskey studies the mechanism of biomineralization via analyses of the composition and structure of mineral and matrix in health and disease, the role of matrix constituents in mineralization, and the development of novel methods to assess mineral and matrix properties. Human conditions of particular interest are: dystrophic calcifications, growth plate abnormalities, osteoporosis, osteoarthritis, and osteogenesis imperfecta. Matrix constituents studied include: phospholipids, collagen, noncollagenous proteins, and proteoglycans. Techniques for analysis include: the gel diffusion system for the study of in vitro mineralization, FT-IR microspectroscopy and imaging and micro-computed tomography for the study of mineral and matrix properties, and wide angle x-ray diffraction. The ultimate goal of the studies is to improve bone quality by providing insight needed for new therapies and tissue engineered products.